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The World Health Organization defines “mental health” “as a state of well-being in which every individual realizes his or her own potential, can cope with the normal stresses of life, can work productively and fruitfully, and is able to make a contribution to her or his community.” In using this definition, S2i recognizes that some mental health challenges reflect brain diseases that, like physical diseases, require appropriate stigma-free and patient-centered care and include both mental health and substance use disorders. Other mental health challenges stem from social conditions and marginalization and require different forms of interventions.